1. Go to 'build' and type
ccmake ../eman2
2. Link all libraries properly.
When using Homebrew, this phase takes a little more care to get right. I suggest comparing your screen to the one I've pasted below (using OS X 10.8):
BOOST_INCLUDE_PATH /usr/local/include BOOST_LIBRARY /usr/local/lib/libboost_python.dylib CMAKE_BUILD_TYPE CMAKE_OSX_ARCHITECTURES CMAKE_OSX_DEPLOYMENT_TARGET CMAKE_OSX_SYSROOT /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platf CMAKE_VERBOSE_MAKEFILE OFF EMAN_INSTALL_PREFIX /Users/jmbell/EMAN2 ENABLE_AUTODOC OFF ENABLE_BOUNDS_CHECKING OFF ENABLE_DEBUG OFF ENABLE_EMAN_CUDA OFF ENABLE_FFTW2 OFF ENABLE_FFTW3 ON ENABLE_FFTW_PLAN_CACHING ON ENABLE_FFT_CACHING OFF ENABLE_FTGL ON ENABLE_HDF5 ON ENABLE_IOCACHE OFF ENABLE_JPEG ON ENABLE_MEMDEBUG OFF ENABLE_MEMDEBUG2 OFF ENABLE_NATIVE_FFT OFF ENABLE_NFFT2 OFF ENABLE_OPENGL ON ENABLE_OPTIMIZE_MACHINE ON ENABLE_OPTIMIZE_MOUNTAIN_LION OFF ENABLE_OPTIMIZE_WINDOWS_VC OFF ENABLE_OPTIMIZE_X86_64 OFF ENABLE_OPTPP OFF ENABLE_PNG ON ENABLE_PROFILE OFF ENABLE_RT ON ENABLE_SPARX_CUDA OFF ENABLE_TIFF ON ENABLE_V4L2 OFF FFTW3_INCLUDE_PATH /usr/local/include FFTW3_LIBRARY /usr/local/lib/libfftw3f.dylib FREETYPE_INCLUDE_PATH /usr/local/include/freetype2 FREETYPE_LIBRARY /usr/local/lib/libfreetype.dylib FTGL_INCLUDE_PATH /usr/local/include FTGL_LIBRARY /usr/local/lib/libftgl.dylib GSL_CBLAS_INCLUDE_PATH /usr/local/include GSL_CBLAS_LIBRARY /usr/local/lib/libgslcblas.dylib GSL_INCLUDE_PATH /usr/local/include GSL_LIBRARY /usr/local/lib/libgsl.dylib HDF5_INCLUDE_PATH /usr/local/include HDF5_LIBRARY /usr/local/lib/libhdf5.dylib JPEG_INCLUDE_PATH /Library/Frameworks/UnixImageIO.framework/Headers JPEG_LIBRARY /usr/local/lib/libjpeg.dylib NUMPY_INCLUDE_PATH /System/Library/Frameworks/Python.framework/Versions/2.7/Extras/l PNG_INCLUDE_PATH /Library/Frameworks/UnixImageIO.framework/Headers PNG_LIBRARY /usr/local/lib/libpng.dylib PYTHON_INCLUDE_PATH /Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platf PYTHON_LIBRARY /usr/lib/libpython2.7.dylib TIFF_INCLUDE_PATH /Library/Frameworks/UnixImageIO.framework/Headers TIFF_LIBRARY /usr/local/lib/libtiff.dylib ZLIB_LIBRARY /usr/lib/libz.dylib