The main documentation for e2refinetorelion3d.py can be found here
e2refinetorelion3d Tutorial
This tutorial is designed with the assumption that the user has installed Relion on their local machine. Though we do not run the relion_refine program on a local machine, several scripts from the Relion installation package are used to prepare the EMAN2 data for a Relion run. Relion can be downloaded here