Make sure you have all EMEN2 dependencies packages installed first. The easiest way to do this is to use an EMAN2 binary package, which provides everything EMEN2 needs to run as well. For EMAN2 binary users on Linux, make sure to use $HOME/Python/bin/python instead of the plain "python" below. You will also not need to "sudo" for easy_install.
mp:~ irees$ sudo easy_install emen2 Searching for emen2 Reading http://pypi.python.org/simple/emen2/ Reading http://blake.grid.bcm.edu/emanwiki/EMEN2/ Best match: emen2 2.1b9 Downloading http://pypi.python.org/packages/source/e/emen2/emen2-2.1b9.tar.gz#md5=84a6f339029f4383cc8766b902330cc2 Processing emen2-2.1b9.tar.gz Running emen2-2.1b9/setup.py -q bdist_egg --dist-dir /tmp/easy_install-zvleeC/emen2-2.1b9/egg-dist-tmp-WPecsd Adding emen2 2.1b9 to easy-install.pth file Installing emen2ctl script to /usr/local/bin Installed /Library/Python/2.7/site-packages/emen2-2.1b9-py2.7.egg Processing dependencies for emen2 Finished processing dependencies for emen2