Rosetta

Thursday PM Practical

Rosetta is an object-oriented software suite which provides a robust system for predicting and designing protein structures, protein folding mechanisms, and protein-protein interactions.

For the tutorial, you can download binaries of Rosetta for:

• Linux: rosetta_binaries_linux-mar7-11.tar.gz

• Mac: rosetta_binaries_mac_mar7_11.tar.gz

• Windows: Sorry. Not available

Afterwards, please add the following two lines in your .bashrc file and do "source ~/.bashrc".

export ROSETTA3_SRC=/home/eman/eman2011/rosetta/rosetta_binaries_linux export ROSETTA3_DB=/home/eman/eman2011/rosetta/rosetta_database

For installation of the standard release, the latest release of Rosetta, version 3.2, may be downloaded at http://www.rosettacommons.org/software. The software is free to academic users, who may get a license (and download link) by clicking on the appropriate link on the left side of the page. The user manual, containing more detailed installation and usage information, is available online at http://www.rosettacommons.org/manuals/archive/rosetta3.2_user_guide.

More details about the installation can be found at: Installation_Guide.pdf

Tutorial data is here: rosetta_tutorial_data.tar

Tutorial documentation is here: Rosetta_Density_Tutorial.pdf (though this will also be handed out at the workshop, and may be updated before thursday)